Grinker’s Myelinopathy

Gisborne Herald – 14 May 2024

A recent paper has taken a detailed look at a rare brain condition known as Grinker’s Myelinopathy, which is caused by oxygen deprivation to the brain due to incidents such as cardiac arrest and drug overdoses. The study introduces dSIR, a form of “Ultra-high contrast MRI.” This new MRI method is based on a mathematical framework developed by Emeritus Professor Graeme Bydder, Associate Professor Ya-Jun Ma, and others.

Based on this framework, Dr Daniel Cornfeld and Paul Condron from the Mātai team discovered a specific set of MRI parameters and developed code that identified the “whiteout sign” as it appears on abnormal white matter. This method shows brain damage not currently visible on clinical MRI. This advancement could change how we view and treat what might be a much more prevalent disorder than previously recognised. Mātai neuropsychiatrist Dr Gil Newburn says, “The lack of visible signs on conventional MRI in disorders such as Grinker’s contributes to misunderstandings, such as the belief that individuals affected are merely lazy, seeking attention, or feigning illness. The attribution of symptoms to personal failings rather than medical disease impedes access to necessary support and treatment. By correctly identifying pathological damage to the brain with ultra-high contrast MRI, we are in a position to offer more effective treatment.”