Research Details

  • Musculoskeletal imaging
  • Gisborne & Auckland, NZ
  • Prof. Thor Besier
    Dr. Manuela Zimmer
  • t.besier@auckland.ac.nz manuela.zimmer@auckland.ac.nz

Figure: An axial slice of the calf imaged using a fast spin-echo sequence (left), and the tractography-reconstructed fibre architecture of the gastrocnemius muscle heads using diffusion tensor imaging (right).

What keeps us moving? Advancing our understanding of musculoskeletal function through imaging

Overview

We use advanced MRI techniques to create detailed images of muscles, tendons, and bones, allowing us to study how the body’s movement system is built and functions. By mapping the internal structure of muscles, we can reveal the arrangement of muscle fibres that generate the muscle force. Specialised imaging methods also enable us to visualise tendons and bones, providing information that is often difficult to obtain with conventional MRI and offering a radiation-free alternative to CT imaging. These unique images help us understand how musculoskeletal tissues change with disease, training, injury, or recovery.

We combine imaging data with computational modelling to create personalised digital representations (“digital twins”) of the musculoskeletal system. These digital twins allow us to investigate movement, injury mechanisms, rehabilitation strategies, and surgical interventions, helping to develop more effective and individualised approaches to musculoskeletal healthcare.

http://Zimmer M, Handsfield G, Condron P, Holdsworth S, Dell’Acqua F, Ates F. Overcoming pitfalls in multi-stack diffusion MRI for tractography reconstruction of skeletal muscles. Sci Rep. 2026 July; 16:22938. doi: 10.1038/s41598-026-63269-6

http://Bin Ghouth S, Besier T, Handsfield G. Statistical Shape and Fibre Orientation Model for Muscle Architecture Characterisation of the Medial Gastrocnemius. Ann Biomed Eng. 2025 Dec;53(12):3376-3388. doi: 10.1007/s10439-025-03866-0. PMID: 41068536

http://Perera MR, Bydder GM, Holdsworth SJ, Handsfield GG. Imaging and Image Processing Techniques for High-Resolution Visualization of Connective Tissue with MRI: Application to Fascia, Aponeurosis, and Tendon. J Imaging. 2025 Feb 4;11(2):43. doi: 10.3390/jimaging11020043. PMID: 39997545

http://Perera MR, Su P, Holdsworth S, Handsfield G. Changes to muscle and fascia tissue after eighteen days of ankle immobilization post-ankle sprain injury: an MRI case study. BMC Musculoskelet Disord. 2025 Jan 9;26(1):34. doi: 10.1186/s12891-024-08254-8. PMID: 39789535

http://Cornfeld D, Condron P, Newburn G, McGeown J, Scadeng M, Bydder M, Griffin M, Handsfield G, Perera MR, Melzer T, Holdsworth S, Kwon E, Bydder G. Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System. Bioengineering (Basel). 2024 Apr 29;11(5):441. doi: 10.3390/bioengineering11050441. PMID: 38790308

http://A statistical shape model of soleus muscle morphology in spastic cerebral palsy. Bin Ghouth SG, Williams SA, Reid SL, Besier TF, Handsfield GG. Sci Rep. 2022 May 11;12(1):7711. doi: 10.1038/s41598-022-11611-z. PMID: 35546597